穿琥宁注射液与24种药物配伍的稳定性考察

Study on the stability of the compatibility of kalii dehydrographolidi succinas injection with 24 drugs

目的 :研究穿琥宁注射液与临床常用 2 4种药物配伍的稳定性。方法 :考察穿琥宁注射液与 2 4种药物在室温下配伍后外观、pH、微粒和紫外吸收度。结果 :穿琥宁注射液与庆大霉素、丁氨卡那霉素、环丙沙星、氧氟沙星配伍产生沉淀 ,与VitC、VitB6 、ATP、辅酶A、胞二磷胆碱、氨茶碱、氢化考的松、地塞米松、三氮唑核苷、阿昔洛韦、双黄连、青霉素钠、氨苄西林钠、红霉素、头孢唑啉钠、头孢哌酮钠、头孢曲松钠、头孢呋辛钠、甲硝唑、替硝唑配伍无显著变化。结论 :穿琥宁注射液不宜与庆大霉素、丁氨卡那霉素、环丙沙星、氧氟沙星配伍 ,可与其他 2

OBJECTIVE:To study the stability of the compatibility of kalii dehydrogrpholidi succinas injection with 24 drugs.METHODS:Under home temperature,the UV absorbance,pH and pariclle of the kalii dehydrographolidi succinas injection with 24 drugs was dettermined by UV,pH meter or pariclle counter for injection,and the aspect was observed too.RESULTS:The comptibility of kalii dehydrographolidi succinas injection with gentamicin,amikacin,ciprofloxacin and ofloxacin appeared precipitation,but with vitamin C,vitamin B 6,adenosinetriphosphate,coenzyme A,natrii citicolini,aminophylline,hydrocortisone,dexamethasone,ribavirin,aciclovir,shuanghuanglian,penicillin,ampicillin,erythromycin,cefazolin,cefoperazone,ceftriaxone,cefuroxime,metronidazole and tinidazoli,no significant change was found in the aspect,pH,particulate and UV absorbance.CONCLUSION:Kalii dehydrographolidi succinas injection could not combine with gentamicin,amikacin,ciprofloxacin and ofloxacin,but could combine with other 20 drugs.