阿糖胞苷在儿童急性淋巴细胞白血病和恶性淋巴瘤病人中的药物浓度监测

Monitor the concentration of high dose cytarabine in children emergent lymphatic leukemia or malignant lympgoma patients

目的 :监测儿童急性淋巴细胞白血病和恶性淋巴瘤病人血液或脑脊液内阿糖胞苷、阿糖胞尿苷的浓度。方法 :用配有SPD -6A紫外可变波长检测器的岛津LC -9A高效液相色谱仪测定药物浓度。结果 :静脉滴注阿糖胞苷 ( 2g/m2 ) ,不同的小儿体内血浆阿糖胞苷浓度呈现个体差异。结论 :为更好发挥疗效 ,同时避免大剂量用药而导致不良反应 ,需对病人 (尤其是儿童 )进行血药浓度监测 。

OBJECTIVE:To monitor the concentration of cytarabine and uracil arabinoside in plasma or cerebrospinal fluid of children emergent lymphatic leukemia or malignant lympgoma patients.METHODS:The drug concentratmion was determined by HPLC.RESULTS:The concentration of cytarabine in plasma was different in individuals at the same dose of cytarabine(0.2g/m 2,iv.gtt).CONCLUSION:In order to avoid ADRs and improve clincal effect,it is necessary to monitor the plasma drug concentration and give the individual dose(especially for children).