摘要
目的:了解抗感染药致严重不良反应的特点,为临床安全、合理用药提供参考。方法:对我院2000～2009年收集到的抗感染药致严重不良反应报告进行分析与评价。结果:114例严重不良反应涉及14种抗感染药。其中居前3位的是抗结核药、头孢菌素类与喹诺酮类。不良反应的临床表现主要为肝损害(占34.59%),其次为肾损害(占26.32%)与皮肤及其附件损害(占14.29%)。108例好转或治愈,3例死亡,2例预后不详,1例有后遗症。38例患者有明确的药物过敏史(33.33%)。结论:常用抗感染药致严重不良反应主要为肝、肾损害,部分患者发生不良反应过程隐匿,若及时发现适当处理,大部分患者可短期内治愈或好转。临床医药人员应根据这些特点加强对相关药物的监测,提高合理用药水平。
OBJECTIVE：To analyze the characteristics of severe ADR induced by antibacterial drugs,and to provide reference for safe and rational use of drugs in the clinic.？METHODS：Severe ADR reports collected from our hospital from 2000 to 2009 were analyzed and evaluated.RESULTS：14 kinds of antibacterial drugs were involved in the study.The top 3 drugs were anti-tuberculosis drug,cephalosporins and quinolones.Main clinical manifestations of ADR were hepatic injury （34.59%）,kidney injury （26.32%） and lesion of skin and its appendants （14.29%）.108 of them were cured or improved,3 cases dead,2 cases unknown of prognosis and 1 case of sequela.38 patients presented with drug hypersensitivity history （33.33%）.CONCLUSION：Main clinical manifestations of severe ADR induced by antibacterial drugs are liver injury and kidney injury.Parts of severe ADR cases happened occult,and they will be cured or improved if they are treated in time.Clinical pharmaceutical staff should pay attention to the monitoring of ADR caused by antibacterial drugs in order to promote rational use of drugs.
出处
《中国药房》
CAS
CSCD
北大核心
2010年第34期3232-3235,共4页
China Pharmacy
