摘要
目的:研究伊曲康唑脂质体在大鼠体内的药动学方法:大鼠尾静脉注射伊曲康唑脂质体及伊曲康唑注射液,建立液相-质谱联用分析(LC-MS/MS)方法测定血浆中的伊曲康唑药物浓度结果:伊曲康唑血浓度在10～1600 ng·ml^(-1)范围内线性良好(r=0.998 9),伊曲康唑脂质体及市售伊曲康唑注射液大鼠体内MRT分别为(3.68±0.19)h和(1.70±0.06)h,AUC分别为(155.47±13.84)mg·L^(-1)·h和(87.12±5.55)mg·L^(-1)·h,差异具有统计学意义(P<0.01)结论:伊曲康唑脂质体具有一定的缓释作用。
Objective： To study the pharmacokinetics of itraconazole liposomes in rats administered i. v. Method： LC-MS/MS method based on positive elect rospray ionization for quantifying itraconazole in rat blood was developed. Itraconazole and internal standard nimodipine were extracted from rats plasma refining sample with protein precipitation by acetonitrile, itraconazole liposomes and itra- conazole injections were administered through tail vein in rat. Result： The linear calibration curves were obtained in the concentration range of 10^-1 600 ng.ml^-1. The lowest limit of quantification was 10. 0 ng.ml^-1. MRT of hraconazole liposomes and itraconazole injections were （3.68 ±0. 19） h and （1.70 ±0. 06） h,AUC were （155.47 ±13.84） mg.L^-1 .h and （87. 12 ±5. 55） mg.L^-1.h,respectively. There were significant difference. Conclusion： Itraconazole liposomes has a certain release role.
出处
《中国药师》
CAS
2010年第9期1238-1240,共3页
China Pharmacist
基金
黑龙江省重点科技项目(GB06C307)
