牛黄解毒滴丸解热镇痛和抗炎作用实验

Study on Antipyretic Analgesic and Anti-inflammatory Effect of Niuhuang Jiedu Dropping Pills

目的:观察牛黄解毒滴丸的解热镇痛和抗炎作用方法:采用2,4-二硝基酚大鼠致热法观察其解热作用;小鼠扭体法、热板刺激法观察其镇痛作用;小鼠耳部肿胀法、大鼠蛋清足肿胀法观察其抗炎作用。结果:牛黄解毒滴丸显著降低2,4-二硝基酚所致大鼠升高的体温;明显减轻和抑制热板所致的小鼠疼痛及醋酸所致的小鼠扭体反应;抑制二甲苯所致的小鼠耳肿胀和蛋清所致的大鼠足肿胀。结论:牛黄解毒滴丸对实验大鼠、小鼠具有良好的解热、镇痛和抗炎作用。

Objective ： To investigate the antipyretie, analgesic and anti-inflammatory effect of niuhuang jiedu dropping pills. Method： Effect of niuhuang jiedu dropping pills on rats with fever model was induced by 2,4-dinitropheny;The analgesic effect was verified by HAt-induced writhing response in mice and hot-plate test;The anti-inflammatory action was assessed by tests including xylene-indueed ear edema in mice and albumin was induced paw edema in rats. Result： Niuhuang jiedu dropping pills significantly reduced the fever induced by 2,4-dinitrophenol in rats;increased the pain thresholdin the hot-plate test;improved the ear edema in mice and the paw edema in rats. Conclusion： Niuhuang jiedu dropping pills has significant antipyretic analgesic and anti-inflammatory activities.