石墨炉原子吸收法测定注射用顺铂中铂的含量

Determination of Pt in Cisplatin for Injection by Graphite Furnace Atomic Absorption Spectrophotometry

目的:建立石墨炉原子吸收法检测注射用顺铂中铂(Pt)的含量。方法:检测波长:265.9 nm,灯电流:12.0 mA,狭缝宽度:0.4 nm,载气流量:200 ml·min^(-1)。结果:Pt在100～500μg·L^(-1)范围内线性关系良好(r=0.999 9),平均加样回收率为99.03%(RSD=0.3%,n=9)。结论:该方法可有效控制注射用顺铂的质量,方法简单、结果准确。

Objective： To establish a method for determination of Pt in cisplatin for injection by graphite furnace atomic absorption spectrophotometry. Method： The determined wavelength was at 265.9 nm, the electric current of the light was 12. 0 mA, the slit-width was 0.4 nm,and the flow rate of burning gas was 200 ml .min^-1. Result： The good linear range of Pt was 100-500 μg.L^-1 （r= 0. 999 9） and the average recovery was 99. 03% （ RSD = 0. 3%, n = 9 ）. Conclusion： The method is simple, accurate, sensitive, and can be used for controlling the quality of cisplatin for injection.