摘要
目的:考察在葡萄糖溶液中,奥沙利铂和胰岛素配伍的稳定性。方法:观察及测定两种注射剂在5%葡萄糖注射液中配伍后于室温放置24 h内外观、pH及不溶性微粒,并采用HPLC法分别测定配伍液中奥沙利铂与胰岛素的含量。结果:配伍液在室温24 h内无变色、气体、沉淀、浑浊等发生,微粒数、pH等无明显变化,奥沙利铂、胰岛素的含量也无明显变化。结论:在实验条件下,奥沙利铂与胰岛素注射液在5%的葡萄糖注射液中配伍24 h内稳定。
Objective： To observe the compatibility of oxalipiatin and insulin for injection. Method： The changes in appearance, particles and pH of the mixture of 5% glucose injection within 24 h at ambient temperature were observed. The concentrations of the ox- aliplatin and insulin were determined by HPLC. Result： There was no evident changes in appearance, no color, gas, precipitation or turbid generated. Also there was no changes in croparticle,pH and the content of oxaliplatin and insulin within 24 h. Conclusion： Insulin injection mixing with oxaliplatin for injection in GS of 5% was stabile within 24h.
出处
《中国药师》
CAS
2010年第9期1307-1309,共3页
China Pharmacist
