摘要
Acetonylacetone 1 与 thiourea，苯胺， glycin 和酸的 glutamic 被对待分别地由 Paal 鈥揔n orr 反应给吡咯衍生物 2， 3， 5，和 9。然后， 3 成功地被转变成相关吡咯由 Mannich 反应的衍生物 4。混合物 6， 7 和 8 被反应获得 5 与由酯化作用反应的 phenethyl 酒精， phenylallylic 白酒和叶酒精分别地。所有新产品的结构被红外， NMR 和 HRMS 系列阐明。
Acetonylacetone 1 was treated with thiourea,aniline,glycine and glutamic acid to give pyrrole derivatives 2,3,5,and 9 by Paal-Knorr reaction,respectively.Then 3 was successfully transformed into the related pyrrole derivative 4 by Mannich reaction. Compounds 6,7 and 8 were obtained by reacting 5 with phenethyl alcohol,phenylallylic alcohol and leaf alcohol by esterification reactions,respectively.The structures of all new products were elucidated by IR,NMR and HRMS spectra.
基金
the State Tobacco Monopoly Bureau(No.110200401014)
Henan Province Office of Education of China(No.2008A208013)
Technology Bureau of Zhengzhou(No.0910SGYN12302) support of this work
