根尖周病变中分泌型IgA的研究

Presence of secretory IgA in human Periapical lesions

选取２５位病人的２５颗尖周病患牙，用火箭免疫电泳技术测定其根管液内分泌型ＩｇＡ浓度。结果显示，尖周病患牙的根管液中含数量不等的分泌型 ｌｇＡ。其浓度仅与患牙是否开放有关，开放的根管中分泌型 ＩｇＡ浓度更高。我们认为，ＩｇＡ存在于体液中并具有局部抗感染的重要作用，而分泌型 ＩｇＡ的作用可能不是消灭抗原而是阻止抗原进入全身免疫系统。

The concentration of secretory IgA in fluids present in the canals of 25 teeth was determined by the rocket immunoelectrophoresis technique. Except for the presence or absence of communication between the oral cavity and the root canals of the affected teeth, no other clinical finding showed significant statistical correlation with the presence of secretory IgA. The canals which were open to the oral flora had significantly higher concentrations of secretory IgA. Immunoglobulin A is present in body fluids and provides the primary defense against local infections. The function of secretory IgA in secretions may act be to destroy antigens but rather to pre, vent access of their substances to the general immunological system.. f