甲基黄酮醇胺对麻醉犬的心血管作用

Cardiovascular effects of methylflavonolamine in anesthetized dogs 1

甲基黄酮醇胺（ＭＦＡ）２和５ｍｇ·ｋｇ－１ｉｖ减慢麻醉犬心率，降低血压，但对左心室收缩压，左心室舒张末压和左心室内压最大上升及下降速率（±ｄｐ／ｄｔｍａｘ）没有显著影响．ＭＦＡ５ｍｇ·ｋｇ－１ｉｖ后３０ｍｉｎ麻醉犬心输出量增加２％，总外周阻力下降１６％；冠脉血流量增加３８％，冠脉阻力下降３９％．ＭＦＡ２和５ｍｇ·ｋｇ－１ｉｖ分别使心肌耗氧指数下降１８％和２３％．研究表明，ＭＦＡ具有增加麻醉犬冠脉血流量，降低心肌耗氧量，降低外周血管阻力的作用．

Cardiovascular effect of methylflavono lamine (MFA) was studied in anesthetized open chest dogs. MFA 2 and 5 mg·kg 1 iv decreased heart rate and mean aortic blood pressure. No significant change was observed in left ventricular systolic pressure, left ventricular end diastolic pressure and maximal rate of rise and decline of left ventricular pressure. After MFA 5 mg·kg 1 iv 30 min, cardiac output and coronary blood flow were increased by 2% and 38%, with total peripheral and coronary vascular resistance decreases by 16% and 39%, respectively. MFA 2 and 5 mg·kg 1 iv reduced the index of myocardial oxygen consumption by 18% and 23%, respectively. The results suggest that MFA increase coronary blood flow, decrease total peripheral vascular resistance and have oxygen spare effect on heart in anesthetized dogs.