摘要
应用数量化理论，建立了线性加权综合评价模型，并提出肝脏毒性指数（ＨＴＩ）作为评价药物肝脏毒性的量化指标．用该法评价了氯丙嗪，黄曲霉毒素的动物肝脏毒性和肝硬化病人的肝损程度．结果表明肝毒指数可综合评价药物的肝脏毒性．
A linear comprehensive evaluation model was established according to the theory of quantification. Based on the model,hepatotoxic index (HTI) was proposed as a quantitative measure for liver injury. This method was successfully applied to the evaluation of animal hepatotoxicity induced by chlorpromazine and aflatoxin and liver injury in patients with cirrhosis. It was demonstrated that HTI may provide a reasonable comprehensive evaluation of hepatotoxicity.
出处
《中国药理学与毒理学杂志》
CAS
CSCD
北大核心
1999年第1期60-64,共5页
Chinese Journal of Pharmacology and Toxicology
基金
安徽省自然科学基金
关键词
药物
肝脏毒性
数量化理论
综合评价
multivariate analysis
theory of quantification
evaluation studies
toxicity
liver
