移植肾急性排斥反应的免疫表型

Immunophenotypes of acute rejection of renal allograft

目的阐明移植肾急性排斥反应的发生机制。方法发生严重急性排斥反应的１６例移植肾行免疫组化染色，其中６例行免疫胶体金电镜观察。结果移植肾组织中主要免疫活性细胞为Ｔ细胞，动脉壁及肾小管细胞间的Ｔ细胞均为ＣＤ８细胞。结论移植肾急性排斥反应主要是由Ｔ淋巴细胞尤其是ＣＤ８细胞介导的一种免疫损伤。

Objective To evaluate the pathogenesis of acute rejection of renal allograft. Methods Immunohistochemical stains were performed on paraffin blocks from 16 renal allografts with severe acute rejection. Six of them have undergone immunogold labeled electron microscopic observation. Results The main inflammatory infiltrates in renal allografts were T lymphocytes. CD 8 lymphocytes were the main immunoactive cells found in tubulitis and arteriolitis. Conclusions The acute rejection of renal allograft is mainly a T lymphocyte, especially CD 8 lymphocyte mediated immunopathologic process.