三七R胶囊质量标准研究

Study on Quality Standard for Sanqi R Granules

目的建立三七R胶囊的质量标准。方法采用HPLC法测定三七R胶囊中三七皂苷R1、人参皂苷Rg1及三七皂苷R2的含量。结果该法测定三七皂苷R1平均回收率为100.62%(RSD=2.99%,n=6);人参皂苷Rg1平均回收率为99.01%(RSD=1.91%,n=6);三七皂苷R2平均回收率为99.66%(RSD=2.38%,n=6)。结论本方法操作简便,结果可靠,准确,能有效地控制三七R胶囊的质量。

Objective To establish the quality standard for Sanqi R Granules.Methods The Shim-Pack C18（250 mm×4.6 mm,5 μm） column was used,with CH3CN-H2O gradually elutied and monitored was at 203 nm,determined the contents of notoginsenoside R1,ginsenoside Rg1 and notoginsenoside R2.Results The average recovery of notoginsenoside R1 was 100.62%（RSD=2.99%,n=6）.The average recovery of ginsenoside Rg1 was 99.01%（RSD= 1.91%,n= 6）.The average recovery of notoginsenoside R2 was 99.66%（RSD= 2.38%,n= 6）,the total contents limit of notoginsenoside R1,ginsenoside Rg1,notoginsenoside R2 shouldn,t be lower than 80 mg/tablet.Conclusion The method is simple,reliable,accurate and can be applied to the quality control of the Sanqi R Granules.