儿童强迫症、抑郁症患者血小板5-羟色胺浓度的比较研究

Comparative study of platelet 5-hydroxytryptamine in children with obsessive-compulsive disorder or depression

目的:通过检测儿童强迫症、抑郁症患者血小板5-羟色胺(5-HT)的浓度,探讨血小板5-HT在儿童强迫症、抑郁症发病中的作用。方法:采用高效液相色谱法检测22例强迫症患儿(包括强迫思维15例,强迫动作7例)和20例抑郁症患儿血小板5-HT的浓度,并与20名正常儿童进行比较。结果:强迫症患儿(173.43±90.67)ng/109和抑郁症患儿(251.62±152.72)ng/109血小板5-HT的浓度低于正常儿童(351.91±170.97)ng/109(P<0.05),强迫症患儿的血小板5-HT的浓度和抑郁症患儿的差异没有显著性(P>0.05)。强迫症患儿中,强迫思维患儿的血小板5-HT的浓度(147.09±44.92)ng/109低于强迫动作患儿(229.88±136.44)ng/109(P<0.05)。结论:儿童强迫症、抑郁症患者血小板5-HT浓度明显下降,并且强迫思维患儿的血小板5-HT浓度与强迫动作患儿的差异有显著性。

Objective：To explore the role of platelet 5-hydroxytryptamine （5-HT） in pathogenesis of obsessive-compulsive disorder and depression by detecting the level of platelet 5-HT in children with obsessive-compulsive disorder or depression.Methods：The level of platelet 5-HT was detected in 22 children with obsessive-compulsive disorder（15 children with obsessive thinking and 7 children with obsessive act） and 20 children with depression, and compared to the 20 health control children.Results：The levels of platelet 5-HT in children with obsessive-compulsive disorder（173.43±90.67）ng/109 and children with depression （251.62±152.72） ng/109 were lower than that in health children （351.91±170.97） ng/109（P0.05）, and there was no significant difference in the levels of platelet 5-HT between children with obsessive-compulsive disorderand children with depression （P0.05）.The level of platelet 5-HT in children with obsessive thinking （147.09±44.92） ng/109 was lowerthan that in children with obsessive act （229.88±136.44） ng/109 （P0.05）.Conclusions：The level of platelet 5-HT decreased significantly in children with obsessive-compulsive disorderor depression, and there was significant difference in the levels of platelet 5-HT between children with obsessive thinking and children with obsessive act.