感染性疾病低蛋白血症发病机制的研究进展

Advances in pathogenesis research of hypoproteinemia in infectious diseases

低蛋白血症是临床许多疾病常见的并发症,可影响疾病预后,尤其是危重症的预后.血清白蛋白降低时,往往提示病情凶险、预后不良.在儿科临床上,低蛋白血症也被视为急性感染的一个常见特征.因此,重视感染后低白蛋白血症发生机制的探讨对临床干预及降低病死率有着至关重要的作用.但感染致低白蛋白血症的发生机制至今尚未完全阐明.本文着重从白蛋白的分解代谢、合成代谢、分布异常、半衰期及蛋白丢失性肠病等方面来阐述感染所致低蛋白血症的可能机制.

Hypoproteinemia is a common clinical complication in many diseases, which could affect the disease prognosis, particularly in critical illness. Low serum albumin level often precludes dangerous conditions and poor prognosis. In the pediatric clinical practice, hypoalbuminemia is commonly seen in acute infection. Therefore, the mechanism of infection-induced hypoalbuminemia should be emphasized, which plays a crucial role in modifying clinical interventions and reducing the mortality rate. But the mechanism of hypoalbuminemia has not yet been fully clarified at present. In this article,the possible mechanism of infectioninduced hypoproteinemia is investigated from the albumin catabolism, synthesis, distribution of abnormalities,half-life, protein-losing enteropathy and so on.