摘要
目的观察辛伐他汀对急性心肌梗死(AMI)患者血清高敏C-反应蛋白(hs-CRP)、内皮素-1(ET-1)、心肌肌酸激酶同功酶(CK-MB)的影响,探讨辛伐他汀在斑块稳定性和炎症反应中的作用。方法选取AMI患者56例,按发病前是否因心绞痛、血脂异常服用过辛伐他汀分为治疗组25例,服用辛伐他汀(20mg,1次/d)4周以上与对照组31例,未服用辛伐他汀。采用放射免疫法、酶联免疫吸附法检测2组患者血清hs-CRP、ET-1、CK-MB水平。结果治疗组血浆hs-CRP、ET-1、CK-MB水平低于对照组,差异有统计学意义(P<0.05)。结论辛伐他汀可抑制炎症反应,改善内皮功能,稳定粥样斑块,缩小心肌梗死范围。
Objective To explore the effects of simvastatin on plaque stability and inflammatory reaction by investigating the serum levels of high sensitive C-reactive protein（ hsCRP） ,endothlin-1（ ET-1） and creatine kinase-MB（ CK-MB） in patients with acute myocardial infarction（ AMI） . Methods Fifty-six patients with AMI were divided into 2 groups： simvastatin treatment group（ n = 25） ： simvastatin was administrated more than 4 weeks before AMI,control group（ n = 31） ： simvastatin was not administrated before AMI. Twenty-four hours after AMI,the serum levels of hs-CRP、ET-1,and CK-MB of all the patients were measured with enzyme-linked immunosorbent assay （ ELISA） and/or immunoradiometric assay （ IRMA） pespectively. Results Serum levels of hsCRP、ET-1 and CK-MB were all much lower in simvastatin treatment group than those in control group（ P 0. 05） . Conclusion Simvastatin could inhibit the inflammatory reaction,ameliorate endothelial function,increase the paque stability and reduce AMI areas.
出处
《中国实用医药》
2010年第25期30-31,共2页
China Practical Medicine
