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瘦素通过细胞因子在RANKL/RANK/OPG系统中的作用对破骨细胞形成的调节 被引量：4

瘦素通过细胞因子在RANKL/RANK/OPG系统中的作用对破骨细胞形成的调节
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摘要 RANKL/RANK/OPG系统是近年来发现的破骨细胞分化过程中的一个重要信号传导通路,是成骨细胞作用于破骨细胞的重要途径。细胞因子与RANKL/RANK/OPG系统关系密切,瘦素通过免疫系统影响细胞因子的分泌进而影响RANKL/RANK/OPG系统的平衡,抑制破骨细胞分化,起到抑制破骨细胞的生成、抑制骨吸收的作用。 RANKL/RANK/OPG system is one of the important signal transduction pathways which isdiscovered in resent years. It is the main way that osteoblast act on osteoclast. Cytokins has a close relationshipwith RANKL/RANK/OPG system. Leptin through the immune system affecting the secretion of cytokines affectthe balance of RANKL / RANK / OPG system. It can inhibit osteoclasts differentiation and the osteoclasts formation and play a role in the inhibition of bone absorption.
作者 高超 周一萌
机构地区 中国医科大学
出处 《中国实用医药》 2010年第25期260-262,共3页 China Practical Medicine
关键词 瘦素 细胞因子 RANKL/RANK/OPG系统 破骨细胞
分类号 R580 [医药卫生—内分泌]
  • 相关文献

参考文献25

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共引文献5

同被引文献44

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引证文献4

二级引证文献15

中国实用医药
2010年 第25期

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