光照对发育期小鼠体重和学习记忆的影响

Effects of light on body weight,learning and memory of growing mice

目的研究不同强度光照对小鼠学习记忆和体重的影响,进一步揭示光污染对人体的危害。方法 50只20日龄小鼠随机分为200 W光照组、100 W光照组、60 W光照组4、0 W光照组及对照组,每组10只。各组小鼠每日于不同光照强度持续照射8 h,连续1周,通过监测体重、跳台实验和Morris水迷宫行为学实验方法,观察光污染对小鼠体重和学习记忆的影响。结果 200 W组的小鼠体重增长率明显低于其他各组,其余4组之间体重增长率差异无统计学意义;光照处理各组与对照组相比,跳台实验潜伏期和错误次数以及Morris水迷宫潜伏期和穿越站台次数没有统计学差异。结论短期高强度光照对小鼠的体重增长有抑制作用,短期光照对于小鼠的学习记忆没有影响。

Objective To study the effects of light on body weight,learning and memory of mice.Methods Fifty mice aged 20 days were randomly assigned to one of the five groups： 200 W light group,100 W light group,60 W light group,40 W light group and normal control group,with 10 in each.They were exposed to different intensities of light 8 hours per day for 1 week.Then we monitored their body weight,examined the mean latency and inaccuracy number in step-down test,and examined the mean latency using a Morris＇ water maze to observe the effect of light pollution on the mice＇s learning and memory.Results Compared with the other four groups,there were significant decelerations of body weight increase in 200 W light group.No significant difference in body weight gain was found among the other four groups.The four light-treatment groups had no significant differences from control group in the mean latency,inaccuracy number in step-down test or the mean latency,or the mean crosses to the target in the Morris＇ water maze.Conclusion Short time high-intensity light can inhibit body weight increase in mice,but short-time light has no effect on the learning and memory of mice.