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电离辐射非靶效应及ICRP的相关评议 被引量：1

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摘要 靶理论是辐射生物学效应的理论核心,其基本内涵是假定细胞至少含有1个遗传关键位点或靶,细胞必须是这个＂靶＂被辐射击中后才会死亡或产生某种效应[1-2].认为靶区以外受到辐射攻击不会引起细胞死亡,而且普遍认同的观点是细胞核DNA就是辐射诱发细胞死亡的靶.早期的研究显示,损伤核DNA产生的细胞死亡效应比细胞膜损伤后发生的效应要大300倍以上[3].
作者 周平坤
机构地区 军事医学科学院放射与辐射医学研究所
出处 《中华放射医学与防护杂志》 CAS CSCD 北大核心 2010年第4期375-378,共4页 Chinese Journal of Radiological Medicine and Protection
基金 国家自然科学基金杰出青年基金（30825011）
关键词 电离辐射 ICRP 靶效应 细胞核DNA 辐射生物学效应 细胞死亡 细胞膜损伤 辐射诱发
分类号 R144 [医药卫生—公共卫生与预防医学]
  • 相关文献

参考文献45

  • 1Marshall M,Gibson JA,Holt PD.An analysis of the target theory of Lea with modern data.Int J Radiat Biol Relat Stud Phys Chem Med,1970,18(2):127-138.
  • 2Marshall M,Holt PD,Gibson JA.Physical parameters of radiations determined from the inactivation of ribonuclease.Int J Radiat Biol Relat Stud Phys Chem Med,1970,18(2):139-146.
  • 3Warters RL,Hofer KG.Radionuclide toxicity in cultured mammalian cells:Elucidation of the primary site for radiationinduced division delay.Radiat Res,1977,69(2):348-358.
  • 4Luce A,Courtin A,Levalois C,et al.Death receptor pathways mediate targeted and non-targeted effects of ionizing radiations in breast cancer cells.Carcinogenesis,2009,30(3):432-439.
  • 5Zhou H,Randers-Pehrson G,Geard CR,et al.Interaction between radiation-induced adaptive response and bystander mutagenesis in mammalian cells.Radiat Res,2003,160 (5):512-516.
  • 6Suzuki M,Zhou H,Geard CR,et al.Effect of medium on chromatin damage in bystander mammalian cells.Radiat Res,2004,162(3):264-269.
  • 7Suzuki M,Zhou H,Hei TK,et al.Effects of irradiated medium on chromatid aberrations in mammalian cells using double mylar dishes.Uchu Seibutsu Kagaku,2004,18(3):110-111.
  • 8Zhou H,Suzuki M,Geard CR,et al.Effects of irradiated medium with or without cells on bystander cell responses.Mutat Res,2002,499(2):135-141.
  • 9Zhou H,Hong M,Chai Y,et al.Consequences of cytoplasmic irradiation:studies from microbeam.J Radiat Res,2009,50(Suppl A):59-65.
  • 10Shao C,Folkard M,Michael BD,et al.Targeted cytoplasmic irradiation induces bystander responses.Proc Natl Acad Sci USA,2004,101(37):13495-13500.

二级参考文献32

  • 1隋建丽,范保星,孙敬芬,周平坤.α粒子诱发人支气管上皮细胞癌变的DNA修复基因表达谱研究[J].癌变．畸变．突变,2004,16(5):257-259. 被引量：3
  • 2魏履新.阳江高本底辐射地区流行病学研究概述（1986—2004年阶段）[J].辐射防护通讯,2006,26(3):1-5. 被引量：7
  • 3Nagasawa H, Little J B. Induction of Sister Chromatid Exchanges by Extremely Low Doses of Alpha-particles. Cancer Res., 1992,52(22) :6394.
  • 4Shao C, Furusawa Y, Kobayashi Y, et al. Involvement of Gap Junctional Intercellular Communication in the Bystander Effect Induced by Broad-beam or Microbeam Heavy Ions. Nucl. Instr. Meth. B, 2006,251(1):177.
  • 5Azzam E I, de Toledo S M, Little J B. Direct Evidence for the Participation of Gap Junction-mediated Intercellular Communication in the Transmission of Damage Signals from Alpha-particle Irradiated to Nonirradiated Cells. Proc. Natl. Acad. Sci. USA., 2001,98(2):473.
  • 6Iyer R, Lehnert B E. Factors Underlying the Cell Growth- related Bystander Responses to Alpha Particles. Cancer Res., 2000,60(5) : 1290.
  • 7Leach J K, Van Tuyle G, Lin P S, et al. Ionizing Radiation-induced, Mitochondria-dependent Generation of Reactive Oxygen/nitrogen. Cancer Res., 2001,61(10) :3894.
  • 8Zhou H, Ivanov V N, Gillespie J, et al. Mechanism of Radiation-induced Bystander Effect: Role of the Cyclooxygenase-2 Signaling Pathway. Proc. Nati Acad. Sci. USA., 2005,102(41 ) : 14641.
  • 9Shao C, Stewart V, Folkard M, et al. Nitric Oxide-mediated Signaling in the Bystander Response of Individually Targeted Glioma Ceils. Cancer Res., 2003,63(23):8437.
  • 10Iyer R, Lehnert B E. Low Dose, Low LET Ionizing Radiation-induced Radioadaptation and Associated Early Responses in Unirradiated Cells. Murat. Res., 2002,503( 1- 2):1.

共引文献20

同被引文献22

  • 1联合国原子辐射效应科学委员会.电离辐射源与效应[M].山西:山西科学技术出版社,2002.
  • 2Griebel J,Nekolla E.Optimisation of patient exposure in CT procedures[EB/OL].(2011-03-31)[2011-08-20]. http://www.eman-network.eu/IMG/pdf/Synth_report_WP1.pdf.
  • 3WHO.WHO handbook on indoor radon:A public health perspective[M].Genava:World Health Organization Available.http://www.who.int/en/.
  • 4中华人民共和国卫生部.GBZ/T 14622002医疗照射放射防护名词术语[S].北京:法律出版社,2002.
  • 5国家质检总局计量司.我们身边的电离辐射[M].北京:中国标准出版社,2005:30-31.
  • 6卫生部卫生法制与监督司公安部三局.全国放射事故案例汇编[G].北京:中国科学技术出版社,2001.
  • 7French Institute of Radioprotection and Nuclear (IRSN).Radioecology[EB/OL].http://www.irsn.fr/EN/librsry/documents/booklet_radioecology.
  • 8Marshall M,Gibson JA,Holt PD.An analysis of the target theory of Lea with modern data[J].Int J Radiat Biol Relat Stud Phys Chem Med,1970,18(2):127-138.
  • 9Marshall M,Holt PD,Gibson JA.Physical parameters of radiations determined from the inactivation of ribonuclease[J].Int J Radiat Biol Relat Stud Phys Chem Med,1970,18 (2):139-146.
  • 10Waters RL,Hofer KG.Radionuclide toxicity in cultured mammalian cells:Elucidation of the primary site for radiation-induced division delay[J].Radiat Res,1977,69 (2):348-358.

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中华放射医学与防护杂志
2010年 第4期

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