生大黄、硫酸镁辅助治疗重症急性胰腺炎的疗效观察

Adjunctive therapeutic effects of rhubarb and magnesium sulfate on severe acute pancreatitis

目的观察生大黄、硫酸镁辅助治疗重症急性胰腺炎的疗效。方法回顾分析我院收治的重症急性胰腺炎患者130例,其中常规组(常规治疗组,42例)、硫酸镁组(常规治疗加硫酸镁组,44例)、生大黄组(常规治疗加生大黄组,44例);分析比较3组的腹痛缓解时间、首次排便时间、血淀粉酶恢复时间、住院时间及总有效率。结果与常规治疗组比较,硫酸镁组和生大黄组腹痛缓解时间、首次排便时间、血淀粉酶恢复时间及住院时间及总有效率均优于常规治疗组,差别有统计学意义(P<0.05);硫酸镁组和生大黄组比较,生大黄组在数值上稍优于硫酸镁组,但差异无明显统计学意义(P>0.05)。结论在常规治疗基础上,联合应用生大黄或硫酸镁治疗重症急性胰腺炎能明显提高临床治疗效果。

Objective To investigate the adjunctive therapeutic effects of rhubarb and magnesium sulfate on severe acute pancreatitis（SAP）.Methods One hundred and thirty patients with SAP were analyzed retrospectively and divided into conventional therapy group A（G-A 42 cases）,magnesium sulfate group B （G-B 44 cases）,and rhubarb group C（G-C 44 cases）.Time of abdominal pain alleviation,serum amylase recovery and first defecation,average duration of hospitalization as well as total effective rate were compared in three groups.Results Compared with G-A,G-B and G-C were much better than G-A with regard to time of abdominal pain alleviation,first defecation,serum amylase recovery,length of hospital stay,total effective rate（P0.05）.Compared with G-B,G-C was a little better,but there was no significant difference statistically（P0.05）.Conclusion Based on conventional therapy,it significantly improved the clinical therapeutic effect when associated with rhubarb or magnesium sulfate,but there is no significant difference between magnesium sulfate and rhubarb adjunctive treatment respectively.