microRNA在HBV相关肝病中的研究进展

Research progress on microRNA in the HBV-related liver disease

microRNA是一类内源性染色体上的非编码单链RNA,能够引起靶mRNA降解或者抑制其翻译,对基因进行转录后的表达调控,在体内发挥诸如发育、细胞分化、细胞增殖、细胞死亡、染色体改变、病毒发病机制和癌变等众多重要的生物学功能。乙型肝炎病毒感染宿主后可发生慢性肝炎、肝硬化、肝衰竭、肝癌等病理变化,乙型肝炎病毒和宿主之间通过miRNA进行的相互调节对HBV相关肝病的发生发展很重要,因此miRNA在HBV相关肝病的研究中具有重要的意义。本文对miRNA在HBV相关肝病中的最新研究进展做一综述。

MicroRNA,which is a class of non-coding single-stranded RNA in endogenous chromosome,can cause degradation of target mRNA or inhibition of its translation as well as subsequent expression and regulation of genes in post-transcription stage.Resultantly,they play important roles in biological functions,such as development,cell differentiation,cell proliferation,cell death,chromosome modifications,virus pathogenesis and oncogenesis.Hepatitis B virus infection of the host may result in many pathological changes such as chronic hepatitis,cirrhosis,liver failure,liver cancer and so on.The interaction between hepatitis B virus and the host by miRNAs is very important to the occurrence and development of HBV-related liver disease,so the studies on miRNAs in HBV-related liver disease hold potential significance.This article makes a summary on latest research progress miRNA in the HBV-related liver disease.