类风湿关节炎患者血清脂联素水平的变化及意义

Change and clinical significance of adiponectin in patients with rheumatoid arthritis

目的研究类风湿关节炎(RA)患者血清脂联素(AD)变化及其意义。方法 ELISA法测定62例RA患者和22例健康志愿者血清中AD水平,同时行实时荧光定量PCR(RT-PCR)检测外周血单个核细胞(PBMC)ADmRNA含量。结果 RA活动组患者血清中AD水平高于RA稳定组和健康对照组(P<0.05),且与DAS28、血沉(ESR)、类风湿因子(RF)呈正相关(P<0.01)。但各组PBMC均未检测到ADmRNA。结论 AD可能在慢性炎症过程中发挥作用,进一步研究AD的来源及参与的病理过程,可能为靶向性治疗RA提供新的思路。

Objective To investigate the change and clinical significance of adiponectin（AD） in patients with rheumatoid arthritis（RA）.Methods ELISA was used to determine the serum level of AD in 62 RA patients and 22 healthy volunteers.The expression of adiponectin in peripheral blood was detected by RT-PCR.Results The level of AD was higher in active RA patients than that in inactive patients and healthy volunteers （P 0.05）.Correlation test indicated that the elevated serum AD level was positively correlated with DAS28,erythrocyte sedimentation rate（ESR） and rheumatoid factor （RF）（P 0.01）.But there was no AD mRNA in peripheral blood detected in this group. ConclusionAD may play an important role in the chronic inflammation of RA.Advanced research focused on the resource of AD and AD-related pathology could provide a new way for the targeting treatment of RA.