佐匹克隆按需治疗脑卒中后失眠症的临床疗效研究

On-demand Zopiclone Treatment of Post-stroke Insomnia

目的观察佐匹克隆按需治疗脑卒中后失眠症的临床疗效与不良反应。方法将80例脑卒中后失眠症患者以随机数字表法分为观察组和对照组,观察组40例,按需口服佐匹克隆片7.5mg/次;对照组40例,连续口服佐匹克隆片7.5mg/d,两组疗程均为4周;采用匹兹堡睡眠质量指数(PSQI)和不良反应量表(TESS)评价疗效和不良反应。结果观察组脱落1例,剩余39例患者中痊愈15例,显著进步13例,好转6例,无效5例;对照组脱落3例,剩余37例患者中痊愈16例,显著进步13例,好转4例,无效4例,两组疗效间差异无统计学意义(u=0.573,P>0.05)。治疗过程中对照组不良反应发生率为32.4%(12/37);观察组不良反应发生率为12.8%(5/39),两组不良反应发生率间差异有统计学意义(χ2=4.21,P<0.05)。结论佐匹克隆按需治疗脑卒中后失眠症的疗效与连续口服的疗效相当,且不良反应少。

Objective To observe the clinical efficacy of on-demand Zopiclone treatment on post-stroke insomnia and its adverse reactions.Methods A total 80 post-stroke insomnia patients were randomly assigned to groups study（n=40） and control（n=40）.The study group were treated with on-demand oral zopiclone tablets,7.5 mg/time,the control with continuous oral Zopiclone Tablets,7.5 mg/d.The course lasted 4 weeks.The effects and adverse reactions were evaluated by Pittsburgh Sleep Quality Index （PSQI） and Treatment Emergent Symptoms Scale （TESS）.Results The effects of group study were similar to that of control （P0.05）.No rebound insomnia,withdrawal reactions and dependence on drugs were noted in treatment course.There was significant difference in TESS between 2 groups （P0.05）.Conclusion On-demand zopiclone treatment of post-stroke insomnia,safe and effective,provides a better treatment options with fewer side effects.