短程NP方案治疗非小细胞肺癌40例观察

Observation on treatment of 40 cases of non-small cell lung cancer with short course of NP regimen

目的研究短程NP方案与经典NP方案治疗晚期非小细胞肺癌(NSCLC)的有效率和毒副反应。方法选取初治晚期NSCLC 80例,随机分为治疗组40例,对照组40例。治疗组:盖诺25 mg/m2,静脉滴注第1、5天;顺铂30 mg/m2,静脉滴注,第1～3天。对照组40例,盖诺25 mg/m2,静脉滴注,第1、8天;顺铂30 mg/m2,静脉滴注,第1～3天。每例均完成两周期同一方案化疗后评价疗效及毒副反应。结果治疗组近期有效率为42.5%,对照组40.0%,两组间有效率比较差异均无显著性(P>0.05),两组毒副反应均以骨髓抑制、恶心呕吐为主,各项毒副作用程度两组基本相似,均未影响治疗。结论短程NP方案治疗晚期NSCLC疗效确切,未增加毒副反应,并可缩短住院时间。

Objective To study the clinicial efficacy and toxic reactions of short course NP regimen and classical NP regimen in the treatment of advanced non-small-cell lung cancer（NSCLC）.Methods Eighty patients with advanced NSCLCs receiving initial treatment were divided into two groups randomly： treatment group：NVB 25 mg/m2,iv gtt on days 1,5;DDP 30 mg/m2,iv gtt on days 1 to 3.Control Group： NVB 25 mg/m2,iv gtt on days 1,8;DDP 30 mg/m2,iv gtt on days 1 to 3.The curative effect and toxic and side effects after two cycles were evaluated.Results Total effective rate was 42.5% in treatment group and 40.0% in control group.The difference between the 2 groups were not obvious（P0.05）.Toxicity reactions were mainly bone marrow inhibition,nausea,vomiting.The two groups had similar toxic reaction and the treatment was not influenced.Conclusion Short course NP regimen has equal clinical effectiveness to classical NP regimen and does not increase toxic reactions,but can cut down length of hospitial stay.