吡柔比星膀胱灌注预防膀胱癌术后复发临床观察

Clinical study of intravesical instillation of pirarubicin (THP) for prevention of postoperative recurrence of bladder cancer

目的分析2006年6月至2009年10月间68例浅表性膀胱癌患者行膀胱部分切除术或行TUR-Bt术后采用吡柔比星(THP)膀胱灌注预防肿瘤复发的疗效。方法 THP30 mg,每周1次,连用8周,而后每月1次,连用10个月,总疗程12个月。结果所有患者均获6～30个月的随访。平均随访12.1个月。复发9例,复发率13.1%。结论 THP用于膀胱灌注预防膀胱癌术后复发有较好的疗效,不良反应少,给药方便,值得临床推广应用。

Objective To investigate the efficacy of intravesical instillation of pirarubicin（THP） in prevention of postoperative recurrence of superficial bladder cancer after partial cystectomy or transurethral resection（TUR-Bt）.Methods Intravesical instillation of 30mg of THP dissolved in 40 ml normal saline and retaining in bladder for 30 minutes was given to the patients once a week for 8 weeks and subsequently once a month for ten months.Results The mean follow up time was 6-30 months,with an average time of 12.1months.The tumor recurrence rate was 13.1%.Conclusion Intravesical instillation of THP is effective for prevention of postoperative recurrence of superficial bladder cancer with few side effect and easy to use,so it can be widely used in such patients.