奥曲肽+奥美拉唑预防肝癌围介入手术期上消化道出血的疗效观察

Effect of Octreotide combined with Omeprazole in prevention from upper gastrointestinal hemorrhage during interventional operation of liver cancer

目的观察奥曲肽+奥美拉唑预防肝癌围介入手术期急性上消化道出血的疗效。方法分析52例原发性肝癌合并门静脉高压症患者,随机分为两组,治疗组26例,对照组26例。治疗组:术前三天使用奥曲肽0.1mgimq8h;奥美拉唑40mgivbid。术后继续使用三天。对照组患者给予心得安10mgpotid。结果治疗组患者住院期间均未发生急性上消化道大出血。对照组患者呕血2例,黑便2例。结论奥曲肽+奥美拉唑对预防肝癌患者围介入治疗期急性上消化道出血有效。

Objective To observe the treatment effect of Octreotide＋Omeprazole in prevention from acute upper gastrointestinal hemorrhage in the period of interventional operation of liver cancer. Method Fifty-two cases of primary liver cancer combined with portal hypertension were randomly assigned into two groups. Twenty-six cases in treatment group were given Octreotide 0.1mg im q8h and Omeprazole 40 mg iv bid three day before operation,and continue used three days after operation. The other 26 cases in control group were given Propranolol 10mg po tid. Result All of patients in treatment group did not occur acute gastrointestinal massive hemorrhage while hospitalization. but 2 cases in control group had hematemesis,and 2 cases with black stools. Conclusion Octreotide＋Omeprazole have good effect in prevent from acute upper gastrointestinal hemorrhage in the period of interventional operation of liver cancer.