原发性肝癌肝动脉化疗栓塞联合三维适形放射治疗的临床应用

The clinical effectiveness of hepatic arterial chemoembolization combined with three dimensional conformal radiotherapy for primary hepatic carcinoma

目的探讨肝动脉化疗栓塞(TACE)联合三维适形放疗(3D-CRT)对原发性肝癌(PHC)的临床应用及疗效。方法对30例原发性肝癌患者,先采用TACE后行3D-CRT。TACE1次者12例,2-3次以上者18例,放射治疗单次分割剂量3-5Gy,总剂量54-64Gy。结果治疗后1年、2年的肿瘤有效率分别为90%、68%。1、2年生存率分别为90%、46.7%。中位生存期20个月,无严重并发症。结论 PHC进行TACE联合3D-CRT治疗是一种有效临床应用方法。

Objective To evaluate the clinical effectiveness of transcatheter arterial chemoembolization（TACE） combined with three-dimensional conformal radiotherapy（3D-CRT） in treating primary hepatic carcinoma. Methods TACE was done before 3D-CRT in 30 patients with primary hepatic carcinoma. Twelve cases adopted TACE one time,and 18 cases adopted TACE two and three times. The single dosage of radiotherapy was 3-5 Gy,and the total radiation dose was 54-64Gy. Results The response rate in one and two years was 90% and 68% respectively,and the survival rate in one and two years was 90% and 46.7%,The median survival time was 20 months. No serious complications occurred. Conclusion TACE combined with 3D-CRT is an effective clinical therapy for the treatment of primary hepatic carcinoma.