摘要
目的:建立呋喃唑酮片的溶出度测定方法。方法:采用桨法,以1.8%的十二烷基硫酸钠为溶出介质,转速100r.min-1,溶出60min,采用紫外分光光度法,在367nm的波长处进行测定。结果:呋喃唑酮在2～12μg·mL-1浓度范围内线性关系良好,A=7.57×10-2C+2.1×10-3,r=0.9999(n=6);平均回收率(n=12)为99.7%;样品溶出度均一性良好。结论:本法快速简便,可作为呋喃唑酮片的质量控制方法。
Objective：To establish the method of dissolution test of furazolidone tablets.Methods：The paddle method was used with 1.8% sodium laurylsulfate as dissolution medium at a rotate speed of 100 r·min-1,dissolution time was 60 minutes.Then it is determined by UV spectrophotometic method with detection wavelength of 367 nm.Results：The linear range of furazolidone was 2-12 μg·mL-1,A=7.57×10-2C＋2.1×10-3,r=0.9999（n=6）;The average recovery （n=12） was 99.7%.Conclusion：This method is rapid and convenient.It can be applied to determine dissolution of furazolidone tablets.
出处
《药物分析杂志》
CAS
CSCD
北大核心
2010年第8期1445-1447,共3页
Chinese Journal of Pharmaceutical Analysis
基金
中国药典2010年版药典科研课题
关键词
呋喃唑酮片
溶出度
紫外分光光度法
furazolidone tablets
dissolution
UV spectrophotometic method
