肾综合征出血热患者血浆内皮素的动态变化及其意义

THE SIGNIFICANCE OF DYNAMIC CHANGE OF PLASMA ENDOTHELIN LEVEL IN HAEMORRHAGIC FEVER WITH RENAL SYNDROME

目的探讨内皮素（ＥＴ）在肾综合征出血热（ＨＦＲＳ）发病机理中的作用。方法对８６例ＨＦＲＳ患者和４０例对照用ＲＩＡ法测定血浆ＥＴ动态变化。结果ＨＦＲＳ患者血浆ＥＴ在发热期、低血压休克期、少尿期和多尿期均显著高于对照组（Ｐ＜０．０５），以少尿期最为显著，恢复期降至正常；同时，ＥＴ与ＨＦＲＳ患者血清ＢＵＮ、Ｃｒ均呈高度正相关，且ＥＴ水平越高，病情越重。结论ＥＴ在ＨＦＲＳ发病过程中起重要作用，动态检测ＥＴ水平对估计病情、预后。

Ojective To ascertain the role of endothelin(ET) in the etiology of haemorrhagic fever with renal syndrome(HFRS).Method ET in plasmas was assayed in 86 hospitalized cases of HFRS patients with RIA,40 healthy adult subjects served as controld.Result It is shown that plasma ET level of the HFRS patients was higher in febrile, hypotensive or shock,oliguric and polyuric stages than that of controls(P<0.05).However,the level returned to normal in stage of recovery.Plasma ET level was also highly correlated with that of BUN and Cr.The higher the level of plasma ET,the poorer the outcome.Conclusion It is suggested that ET plays an important role in the etiology of HFRS and monitoring of plasma ET level will be helpful not only in predicting the prognosis,but also in guiding the clinical therapy.