米索前列醇用于足月妊娠引产的临床研究

CLINICAL STUDY ON INDUCTION OF LABOR IN FULL TERM PREGNANCY BY MISOPROSTOL

目的探讨米索前列醇用于足月妊娠引产的临床应用价值。方法将２３６例符合引产指征的单胎、头位，尚未临产的孕妇随机分为米索前列醇引产组及催产素引产组。结果米索前列醇用于足月妊娠引产的有效率为９４．３％，显著高于催产素组７８．３％（Ｐ＜０．０１）；其临产发动时间及总产程分别为２．８１±０．４９ｈ和６．４０±２．３１ｈ，短于催产素的３．９８±０．２９ｈ及９．１２±２．５０ｈ（Ｐ＜０．０１）；剖宫产率为９．０４％；亦显著低于催产素组（１９．１４％）（Ｐ＜０．０１）；两组胎儿宫内窘迫发生率、新生儿体重及Ａｐｇａｒ评分、产后出血量均无显著差异（Ｐ＞０．０５）。结论米索前列醇用于足月妊娠引产疗效显著，安全、方便，而且有利于计划分娩。

Objective To investigate the clinical value of misoprostol for labor induction in full term pregnancy.Method 236 pregnant women with single pregnant,vertex present,not beginning of active labor selected in study group.The 236 women were randomized into misoprostol group and oxytocin group.Result The effective rate of induction labor was 94.3%,78.3% in misoprostol group and oxytocin group,respectively.The average duration from administration to start of labor in two groups was 2.81±0.49 hours and 3.98±0.69hours,respectively,the average duration from start to vaginal delivery was 6.40±2.31 hours and 9.12±2.50 hours,respectively, The differences were significant between misoprostol group and oxytocin grop(P<0.01).The incidence of fetal distress,neonatal weight,apgar score of neonates and postpartum bleeding had no statistics significant difference between two groups(P>0.05).Conclusion Misoprostol is an efficient and safe for labor induction in full term pregnancy.