增强MRI诊断硬膜周围纤维化的实验研究

MIR Enhanced with Gadolinium for Diagnosis of Peridural Fibrosis:Am Experimental Study in Rats

将２４只ＳＤ大鼠随机分为：聚合纤维素、透明质酸钠、游离脂肪移植和空白对照四组。通过椎板切除后不同材料间置，８周后应用磁显葡胺增强ＭＲＩ扫描、光镜切片、计算机瘢痕面积和硬膜粘连范围图象定量分析，观察研究了增强ＭＲＩ对硬膜周围纤维化的定性与定量诊断。结果显示：增强ＭＲＩ能清晰地显示出各组间硬膜周围纤维化程度的差异（Ｐ＜０．０５），并且，ＭＲＩ信号强度与硬膜外瘢痕面积呈正相关（Ｒｓ＝０．７４，Ｐ＜０．０１）。说明增强ＭＲＩ不仅能对硬膜周围纤维化作出灵敏的定性诊断，同时对纤维化程度亦可作出初步的定量诊断。

Rats were divided randomly into four groups:polycarboxymethycellulose,sodium hyaluronate,free fat and control.Each materiel was applied to the peridura after laminectomy.At 8 weeks after operation,MRI enhanced with gadolinium and computed imaging analysis were used to determinant the effective of it in the qualitative and quantitative diagnosis of peridural fibrosis.The results suggested that the single intensity of enhanced MRI can effectively reflected the degree of the peridural fibrosis in each group,and it is positively correlated with scar area(mm3)obtained though computed analysis(Rs=0 74,P<0 01),which indicate that enhanced MRI not only can qualitatively diagnose peridural fibosis,but also may present an indicator of primary quantitative analysis.