摘要
目的:比较舒马曲坦注射剂与麦角胺咖啡因片剂治疗偏头痛的疗效。方法:72例偏头痛病人分为2组,舒马曲坦组40例(男性4例,女性36例;年龄40a±s15a)用舒马曲坦6mg,sc;麦角胺咖啡因组32例(男性6例,女性26例;年龄39a±16a),口服麦角胺咖啡因2片。结果:用药2h后,舒马曲坦组和麦角胺咖啡因组完全缓解率分别为70%和31%,总缓解率为88%和50%(P<0.01)。用药15min至2h,舒马曲坦组缓解率、起效速度均明显优于麦角胺咖啡因组,15min和2h时分别为25%和6%,88%和50%,(P<0.01)。2组不良反应均轻微短暂。结论:舒马曲坦注射剂治疗偏头痛优于麦角胺咖啡因片剂。
AIM: To compare the efficacies of sumatriptan injection (Sum) vs ergotamine and caffeine tablet (Erg) on migraine. METHODS: Seventy_two patients with migraine were divided into 2 groups. The Sum group of 40 patients (M 4, F 36, age 40 a±s 15 a) received sumatriptan 6 mg sc. The Erg group of 32 patients (M 6, F 26, age 39 a±16 a) received ergotamine and caffeine tablet 2 tab, po. RESULTS: Two hours after dosing, the complete remission rates were 70% vs 31%, and the total clinical remission rates were 88% vs 50%(P<0.01). From 15 min to 2 h after dosing, sumatriptan was superior to ergotamine and caffeine tablet at the rate of remission, 25% vs 6% at 15 min; 88% vs 50% at 2 h, respectively (P<0.01). The adverse reactions were all mild. CONCLUSION: Sumatriptan injection is superior to ergotamine and caffeine tablet.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
1999年第2期82-84,共3页
Chinese Journal of New Drugs and Clinical Remedies