疏肝健脾汤防治肠易激综合征的临床及实验研究

Clinical and Experimental Study on Irritable Bowel Syndrome Treated With“Liver-Soothing and Spleen-Strengthening Decoction”

根据肠易激综合征（ＩＢＳ）肝郁气滞和脾虚的病机特征，制定疏肝健脾法为主的中药（柴胡、白芍、防风、白术、茯苓、陈皮、香附、枳壳、木香、炮姜、乌梅）进行临床和实验前瞻性研究。临床观察表明：中药组（３０例）能有效改善ＩＢＳ患者的临床症状与体征，与思密达西药组（２３例）比较，显效率和有效率有显著差异（Ｐ＜００５）。动物实验证实，中药不同剂量组与西药得舒特组均能拮抗由新斯的明所致小肠过度痉挛，大剂量中药组疗效优于小剂量中药组。

Abstract In accordance with the features of liver qi stagnation and spleen deficiency in irritable bowel syndrome(IBS),Chinese herbal drugs that can soothe the liver and strengthen the spleen in predominance(Radix Bupleuri,Radix Paeoniae Alba,Radix Ledebouriellae,Rhizoma Atractylodis Macrocephalae,Poria,Pericarpium Citri Reticulatae,Rhizoma Cyperi,Fructus Aurantii,Radix Aucklandiae,Rhizoma Zingiberis Recens(baked),Fructus Mume)were selected for an expecting study clinically and experimentally.The clinical observation showed that Chinese herbal group(30 cases)can effectively improve clinical symptoms and signs in IBS patients.In comparison with the Smecta group,there was a significant difference in the obvious effective rate and effective rate( P <0 05).The animal experimental study proved that both Chinese herbal group in different doses and the Dicetel group could antagonize excessive spasm of the small intestine,caused by neostigmine,and that the therapeutic effect in Chinese herbal drug group with large dose was better than that in Chinese herbal drug group in small dose.