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唑来膦酸治疗多发性骨髓瘤骨痛的疗效 被引量:11

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摘要 目的:观察唑来膦酸在多发性骨髓瘤患者不同程度骨骼病变中的治疗作用。方法:按疼痛分级标准比较治疗前后骨痛缓解情况,检测治疗前后血钙水平变化情况,比较骨骼X线片影像学的改变,以及观察药物不良反应的发生。结果:唑来膦酸能降低各种骨骼病变的血钙水平和减轻骨痛,未见严重不良反应。结论:唑来膦酸能减轻多发性骨髓瘤骨痛。
出处 《实用医学杂志》 CAS 北大核心 2010年第17期3223-3224,共2页 The Journal of Practical Medicine
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参考文献10

  • 1Kyle R A, Rajkumar S V. Multiple Myeloma [J]. N Engl J Med, 2004,351(18) : 1860-1873.
  • 2白海涛,王椿.双膦酸盐类药物治疗多发性骨髓瘤[J].世界临床药物,2005,26(6):364-367. 被引量:2
  • 3王焰,沈志祥.多发性骨髓瘤骨病研究进展[J].上海医学,2007,30(3):214-216. 被引量:6
  • 4Tassone P, Forciniti S, Galea E, et al. Growth inhibition and synergistic induction of apoptosis by zoledronate and dexamethasone in human myeloma cell lines [J]. Leukemia, 2000,14 (5) : 841.
  • 5Wood J, Bonjean K, Ruetz S, et al. Novel antiangiogenic effects of the bisphosphonate compound zoledronie acid [J]. J Pharmacol Exp Ther, 2002,302 ( 3 ) : 1055.
  • 6Kunzmann V, Bauer E, Feurle J, et al. Stimulation of gammadeha T cells by aminobisphosphonates and induction of antiplasma cell activity in multiple myeloma [J]. Blood, 2000, 96(2) :384.
  • 7Barille S, Akhoundi C, Collette M, et al. Metalloproteinases in multiple myeloma: production of matrix metalloproteinase-9 (MMP-9), activation of pro MMP-2, and induction of MMP-1 by myeloma cells [J]. Blood, 1997,90(4) : 1649.
  • 8Major P, Lortholary A, Hon J, et al. Zoledronic acid is superior to pamidronate in the treatment of hypercalcemia of malignancy: a pooled analysis of two randomized, controlled clinical trials [J]. J Clin Oncol, 2001,19(2):558.
  • 9Rosen L S, Gordon D, Kaminski M, et al, Zoledronic acid versus pamidronate in the treatment of skeletal metastases in patients with breast cancer or osteolytic lesions of multiple myeloma: a phase Ⅲ, double-bllnd, eomparativetrial [J]. Cancer J, 2001,7 (5) : 377.
  • 10Rosen L S, Gordon D, Kaminski M, et al. Long-term efficacy and safety of zoledronic acid compared with pamidronate disodium in the treatment of skeletal complications in patients with advanced multiple myeloma or breast carcinoma: a randomized, double-blind, multicenter, comparative trial [J]. Cancer, 2003,98 (8) :1735.

二级参考文献8

  • 1Yeh HS,Berenson JR.Myeloma hone disease and treatment options.Eur J Cancer,2006,42:1554-1563.
  • 2Hata H.Bone lesions and macrophage inflammatory protein-1 alpha(MIP-la)in human multiple myeloma.Leuk Lymphoma,2005,46:967-972.
  • 3Terpos E,Szydlo R,Apperley JF,ct al.Soluble receptor activator of nuclear factor kappaB ligand osteoprotegerin ratio predicts survival in multiple myeloma:proposal for a novel prognostic index.Blood,2003,102:1064-1069.
  • 4Alexandrakis MG,Passam FH,Sfiridaki A,et al.Elevated serum concentration of hepatocyte growth factor in patients with multiple myeloma:correlation with markers of disease activity.Am J Hematol,2003,72:229-233.
  • 5Silvestris F,Lombardi L,De Malteo M,et al.Mye[oma bone disease:Pathogenetic mechanisms and clinical assessment.Leuk Res,2007,31:129-138.
  • 6Lacy MQ,Dispenzieri A,Gertz MA,et al.Mayo clinic consensus statement for the use of bisphosphonates in multiple myeloma.Mayo Clin Proc,2006,81:1047-1053.
  • 7Heider U,Kaiser M,Muller C,et al.Bortezomib increases osteoblast activity in myeloma patients irrespective of response to treatment.Eur J Haematol,2006,77:233-238.
  • 8Dewar AL,Farrugia AN,Condina MR.et al.Imatinib as a potential antiresorptive therapy for bone disease.Blood,2006,107:4334-4337.

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