藿香正气软胶囊治疗功能性消化不良的机制研究

Mechanism of Huoxiangzhengqi Soft Capsule in treatment of functional dyspepsia

目的探讨藿香正气软胶囊治疗功能性消化不良的作用机制。方法 采用夹尾致大鼠功能性消化不良模型进行实验,观察藿香正气软胶囊的疗效。结果藿香正气软胶囊明显改善大鼠外观症状,增加体质量,增加胃电频率,促进胃排空及小肠推进,对胃电幅度无明显影响;明显增加血清胃动素及P物质的量,明显减少血管活性肠肽的量及NO的释放,对生长抑素无明显影响。结论藿香正气软胶囊通过增加胃动素、P物质,减少血管活性肠肽、NO的量达到促进胃肠运动的目的。

Objective To investigate the mechanism of Huoxiangzhengqi Soft Capsule in treatment of functional dyspepsia. Methods Cliping tail was used to establish experimental model of functional dyspepsia, then the therapeutic effects of Huoxiangzhengqi Soft Capsule on functional dyspepsia were observed and evaluated. Results Huoxiangzhengqi Soft Capsule improved significantly the appearance, increased body weight and gastric electrical frequency, promoted gastric emptying and intestinal propulsion, but it had no significant effect on gastric electrical amplitude. There was a remarkable increase in serum motilin and P substances in group of Huoxiangzhengqi Soft Capsule. Huoxiangzhengqi Soft Capsule also significantly reduced vasoactive intestinal polypeptide（ VIP）content and NO releasing, and had no significant effect on secretion of somatostatin. Conclusion Huoxiangzhengqi Soft Capsule can promote the gastrointestinal motility by increasing secretion of motilin and P substances and reducing VIP and NO concentration.