精制原人参二醇皂苷对小鼠学习记忆的影响

Effect of notoginseng saponins with high concentration of protopanaxadiol on learning and memory of mice

目的研究精制原人参二醇皂苷(PDS)对亚硝酸钠、乙醇和东莨菪碱所致小鼠记忆障碍的改善作用。方法 连续给精制PDS组、阳性对照药石杉碱甲组小鼠ig相应药物2周,正常和模型对照组小鼠ig等量生理盐水,末次给药1h后,除空白组sc等量生理盐水外,其余各组均立即sc亚硝酸钠、或乙醇、或东莨菪碱,用被动回避实验观察PDS对小鼠学习记忆功能的影响,并比较精制PDS与粗品PDS、人参皂苷Rb1单体的改善学习记忆的作用。结果精制PDS各剂量均有良好的改善小鼠记忆障碍的作用;与精制PDS相比,同样剂量的粗品PDS和人参皂苷Rb1单体则均未显示改善记忆的作用。结论精制PDS是极有前途的益智药物或保健产品的原料。

Objective To investigate the effects of notoginseng saponins containing high-concentration protopanaxadiol （PDS） on dysmnesia of mice induced by sodium nitrite, ethanol and scopolamine. Methods Mice in experimental groups were intragastrically administrated tested drugs for two weeks continuously, and mice in normal group and model control group were intragastrically administered the same amount of physiological saline. The functions of improving learning and memory of PDS were evaluated by using passive shock avoidance paradigm, and were compared with those of crude PDS and single saponins Rbl. Results The results showed that different doses of refined PDS improved significantly the memory disorder of mice. But the same doses of single ginsenoside Rb1 and crude PDS had no effects on scopolamine-induced dysmnesia. Conclusion High concentration of PDS may be quite promising materials of nootropics drugs and health products.