摘要
目的：探索中药复方化痰愈心汤及功能药组的钙拮抗作用。方法：用４５Ｃａ跨膜技术测量大鼠主动脉３种钙通道的Ｃａ２＋内流影响。结果：当复方浓度为０．５～５ｍｇ／ｍｌ时，能阻滞大鼠主动脉ＲＯＣ和ＰＤＣ的Ｃａ２＋内流；功能药组的钙拮抗作用以活血组和行气组较好。结论：化痰愈心汤治疗冠心病的机理可能与阻滞细胞膜外Ｃａ２＋内流有关，其作用规律与Ｖｅｒａｐａｍｉｌ相似。
Objective:To study the Ca 2+ antagonistic effect of functional groups of Huatanyuxin decoction.Method:The 45 Ca transmembrane influx technique was used to measure the Ca 2+ blocking effect of leak,receptor operated Ca 2+ channel (ROC) and potential dependent Ca 2+ channel (PDC) in rat aorta.Result:ROC and PDC could be blocked when the complex prescription was used at concentrations of 0.5～5mg/ml.Among the functional groups,Huoxue group (activating blood) and Xinqi group (promoting and normalizing flow of vital energy)showed better Ca 2+ antagonistic effect.Conclusion:The mechanism of therapeutic effect of Huatanyuxin decoction may be related to its Ca 2+ blocking effect similar to verapamil.
出处
《中国中药杂志》
CAS
CSCD
北大核心
1999年第4期232-233,共2页
China Journal of Chinese Materia Medica
基金
国家自然科学基金
国家教委辐射物理及技术开放实验室资助
关键词
中药复方
钙拮抗剂
化痰愈心汤
钙45
complex prescription
calcium antagonist
radionuclide 45 Ca
