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术前血清IP-10、Mig和BLC水平与移植肾排异关系的研究 被引量：2

IMPACT OF PRE-TRANSPLANT SERUM LEVELS OF IP-10,MIG AND BLC ON ACUTE REJECTION EPISODE
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摘要 目的：研究术前血IP-10、Mig和BLC水平与移植肾排异的关系。方法：2005-08-2009-12行同种异体尸体肾移植（renal transplantation,RTx）手术、肾穿病理证实的急性排异（acute rejection,AR）及肾移植状态（RTx status,Ts）受者149例。总结两组受者术后6mo内AR的发生等流行病及临床资料,用ELISA法检测RTx受者术前血清IP-10、Mig和BLC水平。结果：AR组病人RTx术前IP-10和BLC血清水平明显高于Ts组（P=0.01;P=0.009）,年龄大的受者AR的风险较低（P=0.03）。术前IP-10血清水平大于3.57pg/mL者,与小于3.57 pg/mL者相比,AR发生率升高（59.74%vs 21.95%）。受者术前IP-10血清水平和年龄是RTx术后6mo内AR的独立危险因素（relative risk：1.565,0.893;95%CI：0.888-2.924,0.814-0.980;P=0.006,0.017）。结论：术前血IP-10水平是RTx术后AR的预测因素。 Objective：To investigate the influence of pre-transplant serum IP-10,Mig and BLC levels on acute rejection（AR） episodes.Methods：A retrospective cohort of 149 patients undergoing renal transplants（RTx） between Aug.2005 and Dec.2009,92 males and 57 females,with their blood samples preserved was studied.69 of 149 recipients had undergone biopsy-proved rejection within first 6 months after RTx;the others,with stable allograft function as RTx status at protocol allograft biopsy,had no AR episode.Clinical and epidemiological data were investigated,retrospectively.The pre-transplant serum levels of IP-10,Mig and BLC were determined by ELISA.Results：Pre-transplant serum IP-10 and BLC levels in recipients undergoing rejection episodes were higher than in non-rejection group.The study showed an increased rate of rejection episode in recipients with serum IP-10 levels above 3.57 pg/mL in comparison with below 3.57 pg/mL（59.74% vs 21.95%）.Pre-transplant serum IP-10 levels and age were independent risk factors of AR within first 6 months after RTx（relative risk：1.565,0.893;95% CI：0.888-2.924,0.814-0.980;P=0.006,0.017）.Conclusion：Pre-transplant serum IP-10 levels are one of independent risk factors to predict AR within first 6 months after RTx.
作者 蒋宇光 彭文翰 陈江华
机构地区 中国医科大学北京顺义医院泌尿外科 浙江大学医学院附属第一医院肾病中心
出处 《内蒙古医学院学报》 2010年第4期375-378,共4页 Acta Academiae Medicinae Neimongol
基金 浙江省卫生厅重点支持项目(2004C23004)
关键词 CXCR3 肾移植 IP-10 急性排异 MIG BLC CXCR3 acute rejection IP-10 Mig BLC renal transplantation
分类号 R654.2 [医药卫生—外科学]
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参考文献10

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同被引文献21

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内蒙古医学院学报
2010年 第4期

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