降纤酶治疗急性脑梗死的对比研究

Comparative study of defibrase for acute cerebral infarction

目的观察降纤酶治疗急性脑梗死的临床疗效。方法１８０例患者随机分治疗组９０例和对照组９０例。治疗组应用降纤酶每次１０Ｕ，每日１次静脉滴注，连用４ｄ。对照组应用低分子右旋糖酐每次５００ｍｌ，每日１次静脉滴注，连用１４ｄ。结果用χ２检验进行统计学分析。结果治疗组治愈２２例（２４．４％），显效４０例（４４．４％），总有效率９０％（８１／９０），对照组总有效率６４．４％（５８／９０）。两组总有效率有显著性差异（Ｐ＜０．０１）。治疗组在发病６ｈ内、２４ｈ内用药的总有效率分别为９３．８％、８７．９％，无显著差异（Ｐ＞０．０５）。结论早期应用降纤酶治疗急性脑梗死有显著疗效。

Objective To observe the therapeutic effect of defibrase for acute cerebral infarction.Methods One hundred and eighty cases with acute cerebral infarction were randomly divided into two groups: 90 cases in the treatment group and 90 cases in the control group.The treatment group was treated with defibrase (10U·d -1 ),iv for 4d. The control group was treated with dextrn-40(500ml·d - 1),iv for 14d. The results were analyzed statistically with x 2 -test. Results In the treatment group,22 cases were cured (24.4%) and 40 cases were improved obviously (44.4%),the total effection rate was 90% (85/90).In the control group the total effection rate was 64.4% (58/90). There were extremely obvious difference between the two groups ( P <0.01). In the treatment group, the gross effection rate was 93.8% within 6h and 87.9% within 24h ( P >0.05). Conclusion The Defibrase for acute cerebral infarition in early stage is obviously effective.