胰岛素样生长因子及其结合蛋白水平在儿童肾病综合征中的变化

INSULIN LIKE GROWTH FACTOR Ⅰ AND IGF BINDING PROTEINS IN CHILDREN WITH NEPHROTIC SYNDROME

目的：了解胰岛素样生长因子（ＩＧＦⅠ）及其结合蛋白（ＩＧＦＢＰｓ）水平在儿童肾病综合征（ＮＳ）中的变化。方法：用免疫放射法和放射免疫法对２０名ＮＳ患儿，即ＮＳ活动期组（ＮＳＡ组，ｎ＝１１）和ＮＳ缓解期组（ＲＥ组，ｎ＝９）进行了血清ＩＧＦⅠ和ＩＧＦＢＰｓ水平测定；并以同年龄组正常儿童（ＮＣ组，ｎ＝１０）作对照。结果：与ＮＣ组比较，ＮＳＡ组血清ＩＧＦⅠ、ＩＧＦＢＰ３明显下降（Ｐ＜００１），ＩＧＦＢＰ１和ＩＧＦＢＰ２均明显升高（Ｐ＜００１）；ＲＥ组的血清ＩＧＦⅠ及ＩＧＦＢＰ１、ＩＧＦＢＰ２和ＩＧＦＢＰ３均可恢复正常；ＮＳＡ组血清ＩＧＦＢＰ３与白蛋白存在明显相关关系（ｒ＝０７６，Ｐ＜００１）。结论：ＮＳ活动期存在着ＩＧＦⅠ和ＩＧＦＢＰｓ的异常改变，但缓解期可完全恢复正常；

Objective:To observe growth retardation in children with nephrotic syndrome(NS).Methods:We measured the serum insulin like growth factor Ⅰ(IGF Ⅰ) and IGF binding proteins(IGFBPs)in 20 patients with active state(NSA) and with remission state(RE) of NS by using immuno radiometric assay and radioimmunoassay. Results:Serum level of IGFBP 1 and IGFBP 2 were increased( P <0 01),IGF Ⅰ and IGFBP 3 were decreased( P <0 01) in NSA in comparison with those in healthy control(NC) individuals,but IGF Ⅰ and all IGFBPs returned to normal in RE.Serum levels of IGFBP 3 and serum albumin in NSA are correlated( r=0 76,P <0 01). Conclusion:The serum level of IGF Ⅰ and IGFBPs have changed in the children with NS in active state,but return to normal in the remission state children.The changes of IGF Ⅰ and IGFBPs may play a role in the growth retardation of NS.