bcl-2和P53在人脑胶质瘤中的表达及其与肿瘤分化的关系

BCL 2 AND P 53 EXPRESSION IN HUMAN BRAIN GLIOMAS AND ITS CORRELATION WITH DIFFERENTIATION OF TUMORS

目的：探讨ｂｃｌ２和Ｐ５３在人脑胶质瘤中的表达及其与肿瘤分化的关系。方法：采用免疫组化ＳＰ法对３５例人脑胶质瘤石蜡标本中ｂｃｌ２和Ｐ５３进行检测。结果：ｂｃｌ２和Ｐ５３蛋白在胶质瘤中的表达率分别为６５７％和３７％。ｂｃｌ２阳性表达主要位于分化较好的星形细胞瘤；而Ｐ５３蛋白表达主要位于分化差的间变性星形细胞瘤和多形性胶质母细胞瘤。Ｐ５３阳性表达与肿瘤恶性度和病理分型均呈正相关。结论：在分化较高的肿瘤中以ｂｃｌ２表达为主，而在低分化肿瘤中以Ｐ５３表达为主。

Objective:To investigate bcl 2 and P 53 protein expression in human brain gliomas.Methods:Surgical specimens from 35 patients with human brain gliomas underwent a routine fixation,embedment with paraffin and immunohistochemical staining with a monoclonal antibody against P 53 protein and a polyclonal antibody against bcl 2.Results:Bcl 2 expression was positive in 65 7% of gliomas,and a positive P 53 expression in 37% was shown.Most astrocytoma was positive bcl 2 whereas most anaplastic astrocytoma and glioblastoma multiply was positive P 53.Conclusion:Most tumors of higher differentiation were showed positive bcl 2,whereas most tumors of lower differentiation were in positive P 53,which may play an important role in regulation of tumors differentiation.