摘要
为了评价血液透析病人HCV 感染状况及对肝功能的影响,对62 例维持性血液透析病人应用第二代酶联免疫吸附试验和逆转录聚合酶链反应检查抗- HCV 和HCVRNA。结果显示:62 例病人中,抗- HCV 阳性IgM27 例(43-6 % ) ,抗- HCVIgG 阳性29 例(46-8 % ) ,HCVRNA阳性34 例(54-8 % ) ,三项任一项阳性者38 例(59-7 % ) ,阳性组与阴性组相比,两者在性别、年龄、肾功能、HBV 标志、EPO 应用、CAPD史无显著差异,而与平均透析时间、输血史、ALT 异常、肾移植史有显著差异。提示血透病人中HCV感染严重,输血为血透病人感染HCV 的主要途径。
In orderto assessthe prevalence of HCVinfection in HDpatients and the effect on the liverfunction,62 patientsin our HDunit were evaluated by using second generation ELISAto detect serum anti HCVantibodies,RT PCRto detectserum HCVRNA,27 patients (43-6 % ) were anti HCV IgMpositive,29patients (46-8 % ) were anti HCVIgGpositive,34 patients (54-8 % ) were HCV RNA positive,thetotal positivity of HCV marker was 59-7 % (37/62)- When comparing the HCV marker positiveand negative group ,there were no significant difference in the sex ,age,renal function ,HBV markers、EPOand history of CAPD;There weresignificant differenceinthe duration of dialysis,history oftransfusion,ALTabnormality and kidneytransplantation-Theresultssuggested that HCVinfectionin HDpatients wasserious,blood transfusion appearsto bethe primaryriskfactor,butnosocomialtransmis sion of HCVin the dialyticenviroment may be present-
出处
《临床肝胆病杂志》
CAS
北大核心
1999年第2期106-108,共3页
Journal of Clinical Hepatology
基金
卫生部科研基金
关键词
丙型肝炎病毒
血液透析
输血
医源性传播
Hepatits C virus Hemodialysis Blood transfusion Nosocomialtransmission