摘要
[目的]探讨阿霉素(ADM)、顺铂(CDDP)作用于肝细胞肝癌(HCC)的细胞凋亡阈值。[方法]采用原代细胞培养技术,研究18例HCC对ADM和CDDP的敏感性。[结果]ADM和CDDP作用于HCC的细胞凋亡阈值分别为1.0μg/ml,1.5μ/ml(临床剂量分别为20mg和30mg)。[结论]寻求抗癌药物的细胞凋亡阈值可减少抗癌药物的临床剂量和多药耐药性的出现。
Purpose]To investigate the apoptotic threshold of ADM and CDDP on hepatocellular carcinoma (HCC). [Method]Sensitivities of ADM and CDDP on HCC were studied by primary cell culture. [Result] The apoptotic threshold of ADM and CDDP were 1.0μg/ml and 1.5μg/ml respectively(its clinical dosages were 20mg and 30mg respectively). [Conclusion] Cnderstanding apoptotic threshold of anticancer drugs may reduce clinical dosages of anticancer drugs and reduce the incidence of multidrug resistance(MDR).
出处
《浙江肿瘤》
CAS
1999年第2期71-73,共3页
基金
广东省科委重点攻关项目基金
广东省卫生厅"五个一科教兴医工程"重点项目基金
关键词
凋亡阈值
肝肿瘤
肝细胞癌
多药耐药性
Apoptotic threshold Liver neoplasms Hepeocellar carcinoma Primary cell cultule Mulhdrug resistance