抗癌药物诱导肝细胞肝癌凋亡阈值的研究

A Study on Apoptotic Threshold of Anticancer Drugs in Hepatocellular Carcinoma

［目的］探讨阿霉素（ＡＤＭ）、顺铂（ＣＤＤＰ）作用于肝细胞肝癌（ＨＣＣ）的细胞凋亡阈值。［方法］采用原代细胞培养技术，研究１８例ＨＣＣ对ＡＤＭ和ＣＤＤＰ的敏感性。［结果］ＡＤＭ和ＣＤＤＰ作用于ＨＣＣ的细胞凋亡阈值分别为１．０μｇ／ｍｌ，１．５μ／ｍｌ（临床剂量分别为２０ｍｇ和３０ｍｇ）。［结论］寻求抗癌药物的细胞凋亡阈值可减少抗癌药物的临床剂量和多药耐药性的出现。

Purpose]To investigate the apoptotic threshold of ADM and CDDP on hepatocellular carcinoma (HCC). [Method]Sensitivities of ADM and CDDP on HCC were studied by primary cell culture. [Result] The apoptotic threshold of ADM and CDDP were 1.0μｇ/ml and 1.5μg/ml respectively(its clinical dosages were 20mg and 30mg respectively). [Conclusion] Cnderstanding apoptotic threshold of anticancer drugs may reduce clinical dosages of anticancer drugs and reduce the incidence of multidrug resistance(MDR).