摘要
目的：建立ＡｇＮＯＲ方法对皮肤良性痣细胞痣与恶性黑色素瘤进行鉴别。方法：用胶银染色一步法，对皮肤１６例恶性黑色素瘤及４５例良性痣细胞痣的ＡｇＮＯＲ进行定量观察。结果：恶性黑色素瘤每个细胞核的ＡｇＮＯＲ数值为９１６±２８２，痣细胞痣每个细胞核的ＡｇＮＯＲ数值为３５０±０７７，两者之间差别有非常显著性意义（（Ｐ＜００１）。结论：ＡｇＮＯＲ计数可作为鉴别诊断皮肤恶性黑色素瘤与良性痣细胞痣的一个有效的指标。
Objective:To differentiate cutaneous malignant melanomas and nevocellular nevi to serve the clinic better.Methods:Using a siliver colloid staining technique in paraffin sections and HI-CI image analysis system.Results:16 cases of cutaneous malignant melanomas and 45 cutaneous nevocellular nevi were detected by image system.The mean number of AgNOR per nucleus in malignant melanoma was 9.16±2.82,and in nevocellular nevi 3.50±0.77,with very marked statistical significance(P<0 01).Conclusion:The quantitative study of AgNOR is of great value in differential diagnosis of benign and malignant cutaneous melanotic lesions.
出处
《内蒙古医学院学报》
1999年第1期18-20,共3页
Acta Academiae Medicinae Neimongol
