摘要
目的：评价甲硝唑降血脂疗效及唾液甲硝唑浓度监测。方法：２３例高血脂症采用口服甲硝唑三种给药方案治疗：Ⅰ．０６ｇｔｉｄ×１０ｄ，ｎ＝６。Ⅱ．０４ｇｔｉｄ×１０ｄ，ｎ＝１０。Ⅲ．０２ｇｔｉｄ×１０ｄ，ｎ＝７。结果：三种方案甘油三酯下降总有效率为６６７％，６００％及４２８％；胆固醇下降总有效率为６６７％，６００％及４２８％。三种方案治疗后血脂下降百分数为：甘油三酯为６２３％，３４６％及３１０％；胆固醇为３０４％，１７５％及１９４％。唾液中甲硝唑Ｃｓ三种方案依次为３１３９，２０６０及１６２０μｇ／ｍｌ。结论：甲硝唑降甘油三酯和胆固醇作用快速、明显。甲硝唑唾液浓度监测ＣＳＳ有剂量依赖性，符合药物动力学规律。
Objective: To evaluation of MN in treatment of hypenlipemia and its saliva drug concentration monitoring. Methods:23 hyperlipemia patients were treated by Metronidazole (MN)orally. Three MN dosage schemes were administrated:(Ⅰ)0 6g tid ×10d,n=6;(Ⅱ)0 4g tid ×10d,n=10;(Ⅲ)0 2g tid×10d,n=7.Results:After 10 days MN therapy, the total curative rates of three schemes for triglyceride were 66.7%,60.0% and 42.8%, for cholesterol were 66.7%,60.0% and 42.8%. The decrease % of serum lipids of three schemes for triglyceride were 62.3%,34.6% and 31.0%, for cholesterol 30.4%,17.5% and 19.4%. The MN saliva C ss of three schemes were 31.39, 20.60 and 16.20 μg/ml.Conclusion: The function of MN bringing down triglyceride and cholesterol is quick and obvious. MN has the dependence on the dosage in determining C ss in salivary concentration.
出处
《内蒙古医学院学报》
1999年第1期25-27,共3页
Acta Academiae Medicinae Neimongol
基金
内蒙古自然科学基金
关键词
甲硝唑
血症过多
甘油三酯
胆固醇
唾液浓度
metronidazole
hyperlipemia
triglyceride, cholesterol
salivary concentration
