奎硫平对难治性抑郁症的辅助治疗作用

Adjunctive Therapeutic Effect of Quetiapine on Refractory Depression

目的观察奎硫平联合文拉法辛治疗难治性抑郁症的疗效和不良反应。方法将90例难治性抑郁症患者随机分为两组,合用组为奎硫平联合文拉法辛,单用组为文拉法辛,疗程6周。以汉密尔顿抑郁量表(HAMD)和汉密尔顿焦虑量表(HAMA)评定临床疗效;以治疗中出现的症状量表(TESS)评定不良反应。结果治疗后两组HAMD和HAMA的评分均显著降低(P<0.01),以合用组疗效显著(P<0.01或P<0.05)。结论奎硫平联合文拉法辛治疗难治性抑郁症的疗效优于单用文拉法辛,不良反应轻。

Objective To explore the effect of venlafaxine combined with quetiapine in the treatment of refractory depression.Methods Totally 90 patients with refractory depression were randomly assigned into two groups,quetiapine combined with venlafxine（combination group） and venlafaxine alone（single group） for 6 weeks.The clinical efficacy were evaluated by the Hamilton Depressive Scale（HAMD） and the Hamilton Anxiety Scale（HAMA）.Adverse effects were assessed by the Treatment Emergent Symptom Scale（TESS）.Results As compared with the baseline scores,the HAMD scores as well as HAMA,the two groups decreased significantly after 6weeks＇treatment（P0.01）,especially for combined group（P0.01orP0.05）.Conclusion The combination of quetiapine with venlafaxine is better than venlafaxine alone in the treatment of refractory depression.