基于组学的中药炮制研究

Study on Material Medica Processing by-Omics Method

建立行之有效的现代中药炮制研究体系,是中医药现代化进程中亟待解决的关键问题之一。本文遵循中医与中药相结合、系统论和还原论相结合、整体与部分研究相结合、体内和体外研究相结合的原则,以中药化学组学作为主要技术支撑,尝试提出包括化学物质基础研究、现代药理学研究、代谢组学研究在内的现代中药炮制研究体系,并结合中药炮制的具体研究实例,对该研究体系指导下的中药炮制现代化研究进行了初步探讨。本文提出的中药炮制研究体系为中药复方的现代研究提供了方法论,将有助于系统、深入地揭示中药炮制的科学内涵,指导新的中药炮制方法研发,更好地传承和发展中医药理论。

Establishment of an available study system for modern processing of Chinese herb medicine is a key step during the TCM development. Based on practice, this paper presents such a study system by combining the traditional Chinese medicine with material medica and the relationship theory with the reductionism both in vivo to in vitro. Covering the studies concerning chemical products, pharmacology and metabonomics , this system will help to further reveal the connotation of Chinese herb processing, thus setting up a guideline for developing processing methods and and the TCM theory with pheytochemiomics as the supporting technology.