周仲瑛诊治系统性红斑狼疮病案的方药配伍特色分析——基于卡方检验及影响度的关联规则方法

Analysis of ZHOU Zhong-ying’effective combination drugs in preventing and teeating systemic lupus erythematosus by association rules based on Chi-squared analysis and influence degree

目的:对周仲瑛治疗系统性红斑狼疮病案中的用药特色进行分析。方法:采用基于卡方检验及影响度的关联规则算法。结果:在选定的支持度与置信度之下,共挖掘出73条规则,单味药与单味药之间的关联规则主要以生地黄、鬼箭羽、漏芦、土茯苓、牡丹皮、狗舌草、赤芍、玄参、紫草、雷公藤、水牛角、露蜂房、苦参、制黄精等之间的关联为主;两味药与两味药之间以生地黄与鬼箭羽、漏芦、土茯苓、牡丹皮、狗舌草、赤芍、紫草等形成的配伍关系为主,与周教授认为系统性红斑狼疮的病理机制"火毒是主因,即诸般兼挟,皆因火毒",从而立清热、解毒、化瘀为基本治疗大法进行辨证用药的思想基本一致。结论:基于卡方检验及影响度的关联规则方法能有效提取周仲瑛教授治疗系统性红斑狼疮的用药经验,从而为名老中医经验的继承提供方法学借鉴。

Objective：To analyse ZHOU Zhong-ying’effective combination drugs in preventing and treating the systemic lupus erythematosus（SLE）.Methods：Association rules based on Chi-squared analysis and influence degree was used.Results：73 Rules of TCM couples were selected in the high frequency drugs distribution,and the drugs were mainly those for heat clearing,antidote medicines and blood act stasis remove medicines,which was in accordance with the main pathological mechanism factor for SLE given by Professor Zhou.Conclusion：The new method could find out many significant TCM couples in the study of the compatibility of TCM.