消斑Ⅰ号对外阴营养不良患者皮损表皮细胞P53蛋白表达的调控作用

Regulation of Recipe Xiaoban No.1 on expression of P53 in dystrophy of vulva

目的:探讨消斑Ι号对外阴营养不良患者皮损表皮细胞P53蛋白表达的调控作用。方法:应用免疫组织化学方法,对30例慢性外阴营养不良患者治疗前与治疗后的皮损表皮细胞以及23名正常人表皮细胞进行P53蛋白检测。结果:各型慢性外阴营养不良患者治疗前P53蛋白表达明显高于正常组,差异有极显著性(P<0.01)。经治疗后,中药治疗增生组、萎缩组P53表达降低,与治疗前比有显著性差异(P<0.05),与正常组比无显著性差异(P>0.05)。结论:中药消斑Ι号能够显著改善临床症状,并能降低皮损表皮细胞P53的阳性表达率,从而达到临床治愈的目的。

Objective：To explore the regulation of Recipe Xiaoban No.1 on the expression of p53 in dystrophy of vulva.Methods：Expression of p53 was determined by immunohistochemical technique in skin lesion of prior treatment and posttreatment from 30 cases with chronic vulvar dystrophy,and normal skin from 23 health adults were served as controls.Results： Expression of p53 in various of chronic dystrophy of vulva before treatment was obviously higher than control group（P0.01）.After treatment with Chinese herbs,expression of P53 of hyperplasia group and atrophy group decreased,there was difference compared with that of prior treatment（P0.05）,but no statistic significance compared with that of control group（P0.05）.Conclusion：Recipe Xiaoban No.1 can obviously improve the clinical symptoms and decrease the expression rate of P53.