人类白血病病毒Ⅰ型致成人T细胞白血病/淋巴瘤的研究进展

Research advance in human T-cell leukemia virus Type Ⅰ-induced adult T-cell leukemia/lymphoma

现已证实人类白血病病毒Ⅰ型(human T-cell leukemia virus Type-1,HTLV-Ⅰ)为成人T细胞白血病/淋巴瘤(adult T-cell leukemia/lymphoma,ATLL)的致病病原,在过去的几年中,人们对该肿瘤进行了大量的研究工作并且发现了一些分子遗传学改变,包括结构基因gag,pol,pro和env,调节基因tax和rex以及最近在pX区域的负股发现的hbz基因和Fra-2等。随着人们对成人T细胞白血病/淋巴瘤相关基因功能的不断探索,该肿瘤的发病机制会更加明确,其临床治疗也会得到进一步的改善。本文对HTLV-Ⅰ及成人T细胞白血病/淋巴瘤近年来的分子遗传学研究结果、临床特征、分子机制及遗传倾向的关系作一介绍。

It has been shown that human T-cell leukemia virus Type-1（HTLV-Ⅰ） could induce adult T-cell leukemia/lymphoma（ATLL）.In the past few years,ATLL has been extensively studied and many of its molecular genetics alterations have been found,which include the structural genes gag,pol,pro and env,the regulatory genes tax and rex as well as the genes located in pX region hbz and Fra-2.With the constant exploration on the gene function of ATLL,the pathogenesis of ATLL will be more clear and therapy for ATLL will be improved.In this review,we summarized recent findings in molecular genetics,clinical features,molecule mechanisms,and genetic predisposition related to HTLV-Ⅰ and ATLL.